Адипонектин

ADIPOQ
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 4DOU
Ідентифікатори
Символи	ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, C1Q and collagen domain containing, Adiponectin
Зовнішні ІД	OMIM: 605441 MGI: 106675 HomoloGene: 3525 GeneCards: ADIPOQ
Онтологія гена Молекулярна функція • hormone activity • signaling receptor binding • cytokine activity • sialic acid binding • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • identical protein binding • extracellular matrix structural constituent Клітинна компонента • cell surface • ендоплазматичний ретикулум • Колаген • extracellular space • extracellular region • GO:0009327 protein-containing complex • collagen-containing extracellular matrix Біологічний процес • positive regulation of glucose import • positive regulation of protein phosphorylation • negative regulation of receptor binding • low-density lipoprotein particle clearance • negative regulation of blood pressure • negative regulation of macrophage differentiation • negative regulation of synaptic transmission • generation of precursor metabolites and energy • cellular response to epinephrine stimulus • negative regulation of gluconeogenesis • regulation of glucose metabolic process • циркадний ритм • fatty acid oxidation • positive regulation of interleukin-8 production • glucose metabolic process • protein heterotrimerization • negative regulation of heterotypic cell-cell adhesion • response to ethanol • negative regulation of inflammatory response • cellular response to cAMP • positive regulation of protein kinase A signaling • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of signal transduction • GO:0051247, GO:0051200 positive regulation of protein metabolic process • negative regulation of fat cell differentiation • response to linoleic acid • detection of oxidative stress • glucose homeostasis • adiponectin-activated signaling pathway • response to tumor necrosis factor • positive regulation of blood pressure • response to nutrient levels • positive regulation of cholesterol efflux • negative regulation of MAP kinase activity • cellular response to insulin stimulus • positive regulation of peptidyl-tyrosine phosphorylation • fatty acid beta-oxidation • negative regulation of tumor necrosis factor production • protein localization to plasma membrane • negative regulation of hormone secretion • protein homooligomerization • response to sucrose • positive regulation of metanephric glomerular visceral epithelial cell development • positive regulation of renal albumin absorption • negative regulation of granulocyte differentiation • response to nutrient • negative regulation of protein autophosphorylation • negative regulation of intracellular protein transport • membrane depolarization • response to glucose • positive regulation of myeloid cell apoptotic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of metanephric mesenchymal cell migration • negative regulation of cell migration • positive regulation of fatty acid metabolic process • brown fat cell differentiation • positive regulation of cAMP-dependent protein kinase activity • positive regulation of glycogen (starch) synthase activity • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of DNA biosynthetic process • positive regulation of protein kinase activity • response to hypoxia • negative regulation of phagocytosis • membrane hyperpolarization • negative regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of monocyte chemotactic protein-1 production • response to glucocorticoid • response to activity • negative regulation of platelet-derived growth factor receptor-alpha signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of ERK1 and ERK2 cascade • negative regulation of macrophage derived foam cell differentiation • regulation of fatty acid biosynthetic process • regulation of signaling receptor activity • negative regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell migration • response to bacterium • positive regulation of cold-induced thermogenesis • negative regulation of cold-induced thermogenesis • GO:0072468 Сигнальна трансдукція Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	9370	11450
Ensembl	ENSG00000181092	ENSMUSG00000022878
UniProt	Q15848	Q60994
RefSeq (мРНК)	NM_001177800 NM_004797	NM_009605
RefSeq (білок)	NP_001171271 NP_004788	NP_033735
Локус (UCSC)	Хр. 3: 186.84 – 186.86 Mb	Хр. 16: 22.97 – 22.98 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

ADIPOQ (англ. Adiponectin, C1Q and collagen domain containing) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 244 амінокислот, а молекулярна маса — 26 414.

Кодований геном білок за функцією належить до гормонів. Задіяний у такому біологічному процесі як поліморфізм. Секретований назовні.

Література

Див. також

• Хромосома 3