TGFB2

TGFB2
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1TFG, 2TGI, 4KXZ
Ідентифікатори
Символи	TGFB2, LDS4, TGF-beta2, transforming growth factor beta 2, G-TSF
Зовнішні ІД	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2
Пов'язані генетичні захворювання
хронічне обструктивне захворювання легень
Онтологія гена Молекулярна функція • type II transforming growth factor beta receptor binding • signaling receptor binding • type III transforming growth factor beta receptor binding • cytokine activity • transforming growth factor beta receptor binding • growth factor activity • protein homodimerization activity • amyloid-beta binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity Клітинна компонента • extracellular region • GO:0005578 Позаклітинна матриця • platelet alpha granule lumen • extracellular space • Аксон • neuronal cell body • collagen-containing extracellular matrix Біологічний процес • розвиток ока • regulation of transforming growth factor beta2 production • response to progesterone • смерть клітини • cardioblast differentiation • positive regulation of integrin biosynthetic process • protein phosphorylation • positive regulation of heart contraction • positive regulation of neuron apoptotic process • Ангіогенез • negative regulation of epithelial cell proliferation • uterine wall breakdown • negative regulation of alkaline phosphatase activity • negative regulation of macrophage cytokine production • positive regulation of cell adhesion mediated by integrin • проліферація • transforming growth factor beta receptor signaling pathway • negative regulation of cell population proliferation • positive regulation of stress-activated MAPK cascade • cell-cell junction organization • extrinsic apoptotic signaling pathway • collagen fibril organization • positive regulation of epithelial cell migration • neutrophil chemotaxis • positive regulation of cell growth • response to wounding • negative regulation of cell growth • positive regulation of cardioblast differentiation • glial cell migration • Загоєння ран • positive regulation of ossification • cardiac muscle cell proliferation • positive regulation of epithelial to mesenchymal transition • odontogenesis • positive regulation of timing of catagen • positive regulation of immune response • regulation of complement-dependent cytotoxicity • positive regulation of protein secretion • Епітеліально-мезенхімальний перехід • embryonic digestive tract development • response to hypoxia • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • heart morphogenesis • platelet degranulation • salivary gland morphogenesis • generation of neurons • negative regulation of immune response • GO:0000767 cell morphogenesis • positive regulation of cell population proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • activation of protein kinase activity • positive regulation of cell division • cardiac epithelial to mesenchymal transition • BMP signaling pathway • cell development • skeletal system development • kidney development • neural tube closure • hair follicle development • outflow tract septum morphogenesis • membranous septum morphogenesis • heart valve morphogenesis • atrioventricular valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • endocardial cushion fusion • atrial septum primum morphogenesis • neural retina development • heart development • male gonad development • кровотворення • embryonic limb morphogenesis • hair follicle morphogenesis • ascending aorta morphogenesis • dopamine biosynthetic process • positive regulation of cell cycle • negative regulation of Ras protein signal transduction • somatic stem cell division • neuron development • inner ear development • uterus development • pathway-restricted SMAD protein phosphorylation • ventricular septum morphogenesis • atrial septum morphogenesis • pharyngeal arch artery morphogenesis • regulation of apoptotic process involved in outflow tract morphogenesis • substantia propria of cornea development • cranial skeletal system development • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • regulation of signaling receptor activity • negative regulation of gene expression • negative regulation of angiogenesis • positive regulation of Notch signaling pathway • SMAD protein signal transduction • positive regulation of pri-miRNA transcription by RNA polymerase II • embryo development ending in birth or egg hatching • regulation of timing of catagen • secondary palate development • regulation of cell population proliferation • regulation of apoptotic process • regulation of MAPK cascade Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	7042	21808
Ensembl	ENSG00000092969	ENSMUSG00000039239
UniProt	P61812	P27090
RefSeq (мРНК)	NM_003238 NM_001135599	NM_009367 NM_001329107
RefSeq (білок)	NP_001129071 NP_003229	NP_001316036 NP_033393
Локус (UCSC)	Хр. 1: 218.35 – 218.44 Mb	Хр. 1: 186.35 – 186.44 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

TGFB2 (англ. Transforming growth factor beta 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 414 амінокислот, а молекулярна маса — 47 748.

Кодований геном білок за функціями належить до факторів росту, мітогенів. Секретований назовні.

Література

Див. також

• Хромосома 1