Нейрегулін-1

NRG1
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1HAE, 1HAF, 1HRE, 1HRF, 3U7U
Ідентифікатори
Символи	NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, neuregulin 1
Зовнішні ІД	OMIM: 142445 HomoloGene: 8509 GeneCards: NRG1
Пов'язані генетичні захворювання
ішемічна хвороба серця, рак щитоподібної залози, хвороба Гіршпрунга
Онтологія гена Молекулярна функція • transmembrane receptor protein tyrosine kinase activator activity • protein tyrosine kinase activator activity • signaling receptor binding • cytokine activity • GO:0001104 transcription coregulator activity • growth factor activity • GO:0001948, GO:0016582 protein binding • chemorepellent activity • receptor tyrosine kinase binding • ErbB-2 class receptor binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ErbB-3 class receptor binding • integrin binding Клітинна компонента • цитоплазма • мембрана • синапс • extracellular region • клітинне ядро • apical plasma membrane • integral component of membrane • neuromuscular junction • клітинна мембрана • Аксон • cell body • integral component of plasma membrane • Дендрит (нейробіологія) • axolemma • external side of plasma membrane • Нуклеоплазма • extracellular space • glutamatergic synapse • GABA-ergic synapse Біологічний процес • cardiac conduction system development • embryo development • positive regulation of Ras protein signal transduction • muscle organ development • oligodendrocyte differentiation • positive regulation of dendritic spine development • mammary gland development • axon ensheathment • cell communication • chemorepulsion involved in interneuron migration from the subpallium to the cortex • positive regulation of cardiac muscle cell proliferation • positive regulation of protein localization to cell surface • positive regulation of striated muscle cell differentiation • проліферація • locomotory behavior • GO:1903363 negative regulation of protein catabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • cardiac muscle cell differentiation • endocardial cell differentiation • heart development • positive regulation of cell growth • cardiac muscle cell myoblast differentiation • positive regulation of peptidyl-tyrosine phosphorylation • synapse assembly • positive regulation of cardiac muscle cell differentiation • positive regulation of axon extension • peripheral nervous system development • Переляк • regulation of protein heterodimerization activity • Загоєння ран • glial cell differentiation • нейробіологія розвитку • ventricular trabecula myocardium morphogenesis • glial cell fate commitment • negative regulation of cardiac muscle cell apoptotic process • GO:0045996 negative regulation of transcription, DNA-templated • regulation of protein homodimerization activity • neurotransmitter receptor metabolic process • positive regulation of protein kinase activity • negative regulation of neuron migration • Нейрогенез • neural crest cell development • MAPK cascade • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of myelination • brain development • negative regulation of secretion • GO:0000767 cell morphogenesis • regulation of cell differentiation • ventricular cardiac muscle cell differentiation • positive regulation of phosphatidylinositol 3-kinase signaling • neuron fate commitment • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • cell migration • positive regulation of cell adhesion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • phosphatidylinositol phosphate biosynthetic process • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • ERBB signaling pathway • activation of protein kinase B activity • regulation of cell motility • peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • ERBB2 signaling pathway • activation of transmembrane receptor protein tyrosine kinase activity • cardiac muscle tissue development • ERBB3 signaling pathway • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • ERBB4 signaling pathway • positive regulation of peptidyl-tyrosine autophosphorylation • myelination in peripheral nervous system • GO:0007243 intracellular signal transduction • postsynapse to nucleus signaling pathway Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	3084	112400
Ensembl	ENSG00000157168	ENSRNOG00000010392
UniProt	Q02297 Q7RTW3	P43322
RefSeq (мРНК)	NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964 NM_001322197 NM_001322201 NM_001322202 NM_001322205 NM_001322206 NM_001322207	NM_001271118 NM_001271119 NM_001271120 NM_001271121 NM_001271122 NM_001271123 NM_001271124 NM_001271125 NM_001271126 NM_001271127 NM_001271128 NM_001271129 NM_001271130 NM_031588
RefSeq (білок)	NP_001153467 NP_001153468 NP_001153471 NP_001153473 NP_001153474 NP_001153476 NP_001153477 NP_001153479 NP_001153480 NP_001309126 NP_001309130 NP_001309131 NP_001309134 NP_001309135 NP_001309136 NP_004486 NP_039250 NP_039251 NP_039252 NP_039253 NP_039254 NP_039256 NP_039258 NP_039251.2 NP_001153471.1 NP_001309130.1	NP_001258047 NP_001258048 NP_001258049 NP_001258050 NP_001258051 NP_001258052 NP_001258053 NP_001258054 NP_001258055 NP_001258056 NP_001258057 NP_001258058 NP_001258059 NP_113776
Локус (UCSC)	Хр. 8: 31.64 – 32.86 Mb	н/д
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

NRG1 (англ. Neuregulin 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 640 амінокислот, а молекулярна маса — 70 392.

Кодований геном білок за функцією належить до факторів росту. Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у клітинній мембрані, ядрі, мембрані. Також секретований назовні.

Література

Див. також

• Хромосома 8