Муцин-16 (англ. Mucin 16, cell surface associated) – білок, який кодується геном MUC16, розташованим у людини на короткому плечі 19-ї хромосоми. Довжина поліпептидного ланцюга білка становить 14 507 амінокислот, а молекулярна маса — 1 519 175.
Послідовність амінокислот
| 10 |
|
20 |
|
30 |
|
40 |
|
50 |
| MLKPSGLPGS |
|
SSPTRSLMTG |
|
SRSTKATPEM |
|
DSGLTGATLS |
|
PKTSTGAIVV |
| TEHTLPFTSP |
|
DKTLASPTSS |
|
VVGRTTQSLG |
|
VMSSALPEST |
|
SRGMTHSEQR |
| TSPSLSPQVN |
|
GTPSRNYPAT |
|
SMVSGLSSPR |
|
TRTSSTEGNF |
|
TKEASTYTLT |
| VETTSGPVTE |
|
KYTVPTETST |
|
TEGDSTETPW |
|
DTRYIPVKIT |
|
SPMKTFADST |
| ASKENAPVSM |
|
TPAETTVTDS |
|
HTPGRTNPSF |
|
GTLYSSFLDL |
|
SPKGTPNSRG |
| ETSLELILST |
|
TGYPFSSPEP |
|
GSAGHSRIST |
|
SAPLSSSASV |
|
LDNKISETSI |
| FSGQSLTSPL |
|
SPGVPEARAS |
|
TMPNSAIPFS |
|
MTLSNAETSA |
|
ERVRSTISSL |
| GTPSISTKQT |
|
AETILTFHAF |
|
AETMDIPSTH |
|
IAKTLASEWL |
|
GSPGTLGGTS |
| TSALTTTSPS |
|
TTLVSEETNT |
|
HHSTSGKETE |
|
GTLNTSMTPL |
|
ETSAPGEESE |
| MTATLVPTLG |
|
FTTLDSKIRS |
|
PSQVSSSHPT |
|
RELRTTGSTS |
|
GRQSSSTAAH |
| GSSDILRATT |
|
SSTSKASSWT |
|
SESTAQQFSE |
|
PQHTQWVETS |
|
PSMKTERPPA |
| STSVAAPITT |
|
SVPSVVSGFT |
|
TLKTSSTKGI |
|
WLEETSADTL |
|
IGESTAGPTT |
| HQFAVPTGIS |
|
MTGGSSTRGS |
|
QGTTHLLTRA |
|
TASSETSADL |
|
TLATNGVPVS |
| VSPAVSKTAA |
|
GSSPPGGTKP |
|
SYTMVSSVIP |
|
ETSSLQSSAF |
|
REGTSLGLTP |
| LNTRHPFSSP |
|
EPDSAGHTKI |
|
STSIPLLSSA |
|
SVLEDKVSAT |
|
STFSHHKATS |
| SITTGTPEIS |
|
TKTKPSSAVL |
|
SSMTLSNAAT |
|
SPERVRNATS |
|
PLTHPSPSGE |
| ETAGSVLTLS |
|
TSAETTDSPN |
|
IHPTGTLTSE |
|
SSESPSTLSL |
|
PSVSGVKTTF |
| SSSTPSTHLF |
|
TSGEETEETS |
|
NPSVSQPETS |
|
VSRVRTTLAS |
|
TSVPTPVFPT |
| MDTWPTRSAQ |
|
FSSSHLVSEL |
|
RATSSTSVTN |
|
STGSALPKIS |
|
HLTGTATMSQ |
| TNRDTFNDSA |
|
APQSTTWPET |
|
SPRFKTGLPS |
|
ATTTVSTSAT |
|
SLSATVMVSK |
| FTSPATSSME |
|
ATSIREPSTT |
|
ILTTETTNGP |
|
GSMAVASTNI |
|
PIGKGYITEG |
| RLDTSHLPIG |
|
TTASSETSMD |
|
FTMAKESVSM |
|
SVSPSQSMDA |
|
AGSSTPGRTS |
| QFVDTFSDDV |
|
YHLTSREITI |
|
PRDGTSSALT |
|
PQMTATHPPS |
|
PDPGSARSTW |
| LGILSSSPSS |
|
PTPKVTMSST |
|
FSTQRVTTSM |
|
IMDTVETSRW |
|
NMPNLPSTTS |
| LTPSNIPTSG |
|
AIGKSTLVPL |
|
DTPSPATSLE |
|
ASEGGLPTLS |
|
TYPESTNTPS |
| IHLGAHASSE |
|
SPSTIKLTMA |
|
SVVKPGSYTP |
|
LTFPSIETHI |
|
HVSTARMAYS |
| SGSSPEMTAP |
|
GETNTGSTWD |
|
PTTYITTTDP |
|
KDTSSAQVST |
|
PHSVRTLRTT |
| ENHPKTESAT |
|
PAAYSGSPKI |
|
SSSPNLTSPA |
|
TKAWTITDTT |
|
EHSTQLHYTK |
| LAEKSSGFET |
|
QSAPGPVSVV |
|
IPTSPTIGSS |
|
TLELTSDVPG |
|
EPLVLAPSEQ |
| TTITLPMATW |
|
LSTSLTEEMA |
|
STDLDISSPS |
|
SPMSTFAIFP |
|
PMSTPSHELS |
| KSEADTSAIR |
|
NTDSTTLDQH |
|
LGIRSLGRTG |
|
DLTTVPITPL |
|
TTTWTSVIEH |
| STQAQDTLSA |
|
TMSPTHVTQS |
|
LKDQTSIPAS |
|
ASPSHLTEVY |
|
PELGTQGRSS |
| SEATTFWKPS |
|
TDTLSREIET |
|
GPTNIQSTPP |
|
MDNTTTGSSS |
|
SGVTLGIAHL |
| PIGTSSPAET |
|
STNMALERRS |
|
STATVSMAGT |
|
MGLLVTSAPG |
|
RSISQSLGRV |
| SSVLSESTTE |
|
GVTDSSKGSS |
|
PRLNTQGNTA |
|
LSSSLEPSYA |
|
EGSQMSTSIP |
| LTSSPTTPDV |
|
EFIGGSTFWT |
|
KEVTTVMTSD |
|
ISKSSARTES |
|
SSATLMSTAL |
| GSTENTGKEK |
|
LRTASMDLPS |
|
PTPSMEVTPW |
|
ISLTLSNAPN |
|
TTDSLDLSHG |
| VHTSSAGTLA |
|
TDRSLNTGVT |
|
RASRLENGSD |
|
TSSKSLSMGN |
|
STHTSMTYTE |
| KSEVSSSIHP |
|
RPETSAPGAE |
|
TTLTSTPGNR |
|
AISLTLPFSS |
|
IPVEEVISTG |
| ITSGPDINSA |
|
PMTHSPITPP |
|
TIVWTSTGTI |
|
EQSTQPLHAV |
|
SSEKVSVQTQ |
| STPYVNSVAV |
|
SASPTHENSV |
|
SSGSSTSSPY |
|
SSASLESLDS |
|
TISRRNAITS |
| WLWDLTTSLP |
|
TTTWPSTSLS |
|
EALSSGHSGV |
|
SNPSSTTTEF |
|
PLFSAASTSA |
| AKQRNPETET |
|
HGPQNTAAST |
|
LNTDASSVTG |
|
LSETPVGASI |
|
SSEVPLPMAI |
| TSRSDVSGLT |
|
SESTANPSLG |
|
TASSAGTKLT |
|
RTISLPTSES |
|
LVSFRMNKDP |
| WTVSIPLGSH |
|
PTTNTETSIP |
|
VNSAGPPGLS |
|
TVASDVIDTP |
|
SDGAESIPTV |
| SFSPSPDTEV |
|
TTISHFPEKT |
|
THSFRTISSL |
|
THELTSRVTP |
|
IPGDWMSSAM |
| STKPTGASPS |
|
ITLGERRTIT |
|
SAAPTTSPIV |
|
LTASFTETST |
|
VSLDNETTVK |
| TSDILDARKT |
|
NELPSDSSSS |
|
SDLINTSIAS |
|
STMDVTKTAS |
|
ISPTSISGMT |
| ASSSPSLFSS |
|
DRPQVPTSTT |
|
ETNTATSPSV |
|
SSNTYSLDGG |
|
SNVGGTPSTL |
| PPFTITHPVE |
|
TSSALLAWSR |
|
PVRTFSTMVS |
|
TDTASGENPT |
|
SSNSVVTSVP |
| APGTWTSVGS |
|
TTDLPAMGFL |
|
KTSPAGEAHS |
|
LLASTIEPAT |
|
AFTPHLSAAV |
| VTGSSATSEA |
|
SLLTTSESKA |
|
IHSSPQTPTT |
|
PTSGANWETS |
|
ATPESLLVVT |
| ETSDTTLTSK |
|
ILVTDTILFS |
|
TVSTPPSKFP |
|
STGTLSGASF |
|
PTLLPDTPAI |
| PLTATEPTSS |
|
LATSFDSTPL |
|
VTIASDSLGT |
|
VPETTLTMSE |
|
TSNGDALVLK |
| TVSNPDRSIP |
|
GITIQGVTES |
|
PLHPSSTSPS |
|
KIVAPRNTTY |
|
EGSITVALST |
| LPAGTTGSLV |
|
FSQSSENSET |
|
TALVDSSAGL |
|
ERASVMPLTT |
|
GSQGMASSGG |
| IRSGSTHSTG |
|
TKTFSSLPLT |
|
MNPGEVTAMS |
|
EITTNRLTAT |
|
QSTAPKGIPV |
| KPTSAESGLL |
|
TPVSASSSPS |
|
KAFASLTTAP |
|
PTWGIPQSTL |
|
TFEFSEVPSL |
| DTKSASLPTP |
|
GQSLNTIPDS |
|
DASTASSSLS |
|
KSPEKNPRAR |
|
MMTSTKAISA |
| SSFQSTGFTE |
|
TPEGSASPSM |
|
AGHEPRVPTS |
|
GTGDPRYASE |
|
SMSYPDPSKA |
| SSAMTSTSLA |
|
SKLTTLFSTG |
|
QAARSGSSSS |
|
PISLSTEKET |
|
SFLSPTASTS |
| RKTSLFLGPS |
|
MARQPNILVH |
|
LQTSALTLSP |
|
TSTLNMSQEE |
|
PPELTSSQTI |
| AEEEGTTAET |
|
QTLTFTPSET |
|
PTSLLPVSSP |
|
TEPTARRKSS |
|
PETWASSISV |
| PAKTSLVETT |
|
DGTLVTTIKM |
|
SSQAAQGNST |
|
WPAPAEETGS |
|
SPAGTSPGSP |
| EMSTTLKIMS |
|
SKEPSISPEI |
|
RSTVRNSPWK |
|
TPETTVPMET |
|
TVEPVTLQST |
| ALGSGSTSIS |
|
HLPTGTTSPT |
|
KSPTENMLAT |
|
ERVSLSPSPP |
|
EAWTNLYSGT |
| PGGTRQSLAT |
|
MSSVSLESPT |
|
ARSITGTGQQ |
|
SSPELVSKTT |
|
GMEFSMWHGS |
| TGGTTGDTHV |
|
SLSTSSNILE |
|
DPVTSPNSVS |
|
SLTDKSKHKT |
|
ETWVSTTAIP |
| STVLNNKIMA |
|
AEQQTSRSVD |
|
EAYSSTSSWS |
|
DQTSGSDITL |
|
GASPDVTNTL |
| YITSTAQTTS |
|
LVSLPSGDQG |
|
ITSLTNPSGG |
|
KTSSASSVTS |
|
PSIGLETLRA |
| NVSAVKSDIA |
|
PTAGHLSQTS |
|
SPAEVSILDV |
|
TTAPTPGIST |
|
TITTMGTNSI |
| STTTPNPEVG |
|
MSTMDSTPAT |
|
ERRTTSTEHP |
|
STWSSTAASD |
|
SWTVTDMTSN |
| LKVARSPGTI |
|
STMHTTSFLA |
|
SSTELDSMST |
|
PHGRITVIGT |
|
SLVTPSSDAS |
| AVKTETSTSE |
|
RTLSPSDTTA |
|
STPISTFSRV |
|
QRMSISVPDI |
|
LSTSWTPSST |
| EAEDVPVSMV |
|
STDHASTKTD |
|
PNTPLSTFLF |
|
DSLSTLDWDT |
|
GRSLSSATAT |
| TSAPQGATTP |
|
QELTLETMIS |
|
PATSQLPFSI |
|
GHITSAVTPA |
|
AMARSSGVTF |
| SRPDPTSKKA |
|
EQTSTQLPTT |
|
TSAHPGQVPR |
|
SAATTLDVIP |
|
HTAKTPDATF |
| QRQGQTALTT |
|
EARATSDSWN |
|
EKEKSTPSAP |
|
WITEMMNSVS |
|
EDTIKEVTSS |
| SSVLRTLNTL |
|
DINLESGTTS |
|
SPSWKSSPYE |
|
RIAPSESTTD |
|
KEAIHPSTNT |
| VETTGWVTSS |
|
EHASHSTIPA |
|
HSASSKLTSP |
|
VVTTSTREQA |
|
IVSMSTTTWP |
| ESTRARTEPN |
|
SFLTIELRDV |
|
SPYMDTSSTT |
|
QTSIISSPGS |
|
TAITKGPRTE |
| ITSSKRISSS |
|
FLAQSMRSSD |
|
SPSEAITRLS |
|
NFPAMTESGG |
|
MILAMQTSPP |
| GATSLSAPTL |
|
DTSATASWTG |
|
TPLATTQRFT |
|
YSEKTTLFSK |
|
GPEDTSQPSP |
| PSVEETSSSS |
|
SLVPIHATTS |
|
PSNILLTSQG |
|
HSPSSTPPVT |
|
SVFLSETSGL |
| GKTTDMSRIS |
|
LEPGTSLPPN |
|
LSSTAGEALS |
|
TYEASRDTKA |
|
IHHSADTAVT |
| NMEATSSEYS |
|
PIPGHTKPSK |
|
ATSPLVTSHI |
|
MGDITSSTSV |
|
FGSSETTEIE |
| TVSSVNQGLQ |
|
ERSTSQVASS |
|
ATETSTVITH |
|
VSSGDATTHV |
|
TKTQATFSSG |
| TSISSPHQFI |
|
TSTNTFTDVS |
|
TNPSTSLIMT |
|
ESSGVTITTQ |
|
TGPTGAATQG |
| PYLLDTSTMP |
|
YLTETPLAVT |
|
PDFMQSEKTT |
|
LISKGPKDVS |
|
WTSPPSVAET |
| SYPSSLTPFL |
|
VTTIPPATST |
|
LQGQHTSSPV |
|
SATSVLTSGL |
|
VKTTDMLNTS |
| MEPVTNSPQN |
|
LNNPSNEILA |
|
TLAATTDIET |
|
IHPSINKAVT |
|
NMGTASSAHV |
| LHSTLPVSSE |
|
PSTATSPMVP |
|
ASSMGDALAS |
|
ISIPGSETTD |
|
IEGEPTSSLT |
| AGRKENSTLQ |
|
EMNSTTESNI |
|
ILSNVSVGAI |
|
TEATKMEVPS |
|
FDATFIPTPA |
| QSTKFPDIFS |
|
VASSRLSNSP |
|
PMTISTHMTT |
|
TQTGSSGATS |
|
KIPLALDTST |
| LETSAGTPSV |
|
VTEGFAHSKI |
|
TTAMNNDVKD |
|
VSQTNPPFQD |
|
EASSPSSQAP |
| VLVTTLPSSV |
|
AFTPQWHSTS |
|
SPVSMSSVLT |
|
SSLVKTAGKV |
|
DTSLETVTSS |
| PQSMSNTLDD |
|
ISVTSAATTD |
|
IETTHPSINT |
|
VVTNVGTTGS |
|
AFESHSTVSA |
| YPEPSKVTSP |
|
NVTTSTMEDT |
|
TISRSIPKSS |
|
KTTRTETETT |
|
SSLTPKLRET |
| SISQEITSST |
|
ETSTVPYKEL |
|
TGATTEVSRT |
|
DVTSSSSTSF |
|
PGPDQSTVSL |
| DISTETNTRL |
|
STSPIMTESA |
|
EITITTQTGP |
|
HGATSQDTFT |
|
MDPSNTTPQA |
| GIHSAMTHGF |
|
SQLDVTTLMS |
|
RIPQDVSWTS |
|
PPSVDKTSSP |
|
SSFLSSPAMT |
| TPSLISSTLP |
|
EDKLSSPMTS |
|
LLTSGLVKIT |
|
DILRTRLEPV |
|
TSSLPNFSST |
| SDKILATSKD |
|
SKDTKEIFPS |
|
INTEETNVKA |
|
NNSGHESHSP |
|
ALADSETPKA |
| TTQMVITTTV |
|
GDPAPSTSMP |
|
VHGSSETTNI |
|
KREPTYFLTP |
|
RLRETSTSQE |
| SSFPTDTSFL |
|
LSKVPTGTIT |
|
EVSSTGVNSS |
|
SKISTPDHDK |
|
STVPPDTFTG |
| EIPRVFTSSI |
|
KTKSAEMTIT |
|
TQASPPESAS |
|
HSTLPLDTST |
|
TLSQGGTHST |
| VTQGFPYSEV |
|
TTLMGMGPGN |
|
VSWMTTPPVE |
|
ETSSVSSLMS |
|
SPAMTSPSPV |
| SSTSPQSIPS |
|
SPLPVTALPT |
|
SVLVTTTDVL |
|
GTTSPESVTS |
|
SPPNLSSITH |
| ERPATYKDTA |
|
HTEAAMHHST |
|
NTAVTNVGTS |
|
GSGHKSQSSV |
|
LADSETSKAT |
| PLMSTTSTLG |
|
DTSVSTSTPN |
|
ISQTNQIQTE |
|
PTASLSPRLR |
|
ESSTSEKTSS |
| TTETNTAFSY |
|
VPTGAITQAS |
|
RTEISSSRTS |
|
ISDLDRPTIA |
|
PDISTGMITR |
| LFTSPIMTKS |
|
AEMTVTTQTT |
|
TPGATSQGIL |
|
PWDTSTTLFQ |
|
GGTHSTVSQG |
| FPHSEITTLR |
|
SRTPGDVSWM |
|
TTPPVEETSS |
|
GFSLMSPSMT |
|
SPSPVSSTSP |
| ESIPSSPLPV |
|
TALLTSVLVT |
|
TTNVLGTTSP |
|
EPVTSSPPNL |
|
SSPTQERLTT |
| YKDTAHTEAM |
|
HASMHTNTAV |
|
ANVGTSISGH |
|
ESQSSVPADS |
|
HTSKATSPMG |
| ITFAMGDTSV |
|
STSTPAFFET |
|
RIQTESTSSL |
|
IPGLRDTRTS |
|
EEINTVTETS |
| TVLSEVPTTT |
|
TTEVSRTEVI |
|
TSSRTTISGP |
|
DHSKMSPYIS |
|
TETITRLSTF |
| PFVTGSTEMA |
|
ITNQTGPIGT |
|
ISQATLTLDT |
|
SSTASWEGTH |
|
SPVTQRFPHS |
| EETTTMSRST |
|
KGVSWQSPPS |
|
VEETSSPSSP |
|
VPLPAITSHS |
|
SLYSAVSGSS |
| PTSALPVTSL |
|
LTSGRRKTID |
|
MLDTHSELVT |
|
SSLPSASSFS |
|
GEILTSEAST |
| NTETIHFSEN |
|
TAETNMGTTN |
|
SMHKLHSSVS |
|
IHSQPSGHTP |
|
PKVTGSMMED |
| AIVSTSTPGS |
|
PETKNVDRDS |
|
TSPLTPELKE |
|
DSTALVMNST |
|
TESNTVFSSV |
| SLDAATEVSR |
|
AEVTYYDPTF |
|
MPASAQSTKS |
|
PDISPEASSS |
|
HSNSPPLTIS |
| THKTIATQTG |
|
PSGVTSLGQL |
|
TLDTSTIATS |
|
AGTPSARTQD |
|
FVDSETTSVM |
| NNDLNDVLKT |
|
SPFSAEEANS |
|
LSSQAPLLVT |
|
TSPSPVTSTL |
|
QEHSTSSLVS |
| VTSVPTPTLA |
|
KITDMDTNLE |
|
PVTRSPQNLR |
|
NTLATSEATT |
|
DTHTMHPSIN |
| TAVANVGTTS |
|
SPNEFYFTVS |
|
PDSDPYKATS |
|
AVVITSTSGD |
|
SIVSTSMPRS |
| SAMKKIESET |
|
TFSLIFRLRE |
|
TSTSQKIGSS |
|
SDTSTVFDKA |
|
FTAATTEVSR |
| TELTSSSRTS |
|
IQGTEKPTMS |
|
PDTSTRSVTM |
|
LSTFAGLTKS |
|
EERTIATQTG |
| PHRATSQGTL |
|
TWDTSITTSQ |
|
AGTHSAMTHG |
|
FSQLDLSTLT |
|
SRVPEYISGT |
| SPPSVEKTSS |
|
SSSLLSLPAI |
|
TSPSPVPTTL |
|
PESRPSSPVH |
|
LTSLPTSGLV |
| KTTDMLASVA |
|
SLPPNLGSTS |
|
HKIPTTSEDI |
|
KDTEKMYPST |
|
NIAVTNVGTT |
| TSEKESYSSV |
|
PAYSEPPKVT |
|
SPMVTSFNIR |
|
DTIVSTSMPG |
|
SSEITRIEME |
| STFSLAHGLK |
|
GTSTSQDPIV |
|
STEKSAVLHK |
|
LTTGATETSR |
|
TEVASSRRTS |
| IPGPDHSTES |
|
PDISTEVIPS |
|
LPISLGITES |
|
SNMTIITRTG |
|
PPLGSTSQGT |
| FTLDTPTTSS |
|
RAGTHSMATQ |
|
EFPHSEMTTV |
|
MNKDPEILSW |
|
TIPPSIEKTS |
| FSSSLMPSPA |
|
MTSPPVSSTL |
|
PKTIHTTPSP |
|
MTSLLTPSLV |
|
MTTDTLGTSP |
| EPTTSSPPNL |
|
SSTSHEILTT |
|
DEDTTAIEAM |
|
HPSTSTAATN |
|
VETTSSGHGS |
| QSSVLADSEK |
|
TKATAPMDTT |
|
STMGHTTVST |
|
SMSVSSETTK |
|
IKRESTYSLT |
| PGLRETSISQ |
|
NASFSTDTSI |
|
VLSEVPTGTT |
|
AEVSRTEVTS |
|
SGRTSIPGPS |
| QSTVLPEIST |
|
RTMTRLFASP |
|
TMTESAEMTI |
|
PTQTGPSGST |
|
SQDTLTLDTS |
| TTKSQAKTHS |
|
TLTQRFPHSE |
|
MTTLMSRGPG |
|
DMSWQSSPSL |
|
ENPSSLPSLL |
| SLPATTSPPP |
|
ISSTLPVTIS |
|
SSPLPVTSLL |
|
TSSPVTTTDM |
|
LHTSPELVTS |
| SPPKLSHTSD |
|
ERLTTGKDTT |
|
NTEAVHPSTN |
|
TAASNVEIPS |
|
SGHESPSSAL |
| ADSETSKATS |
|
PMFITSTQED |
|
TTVAISTPHF |
|
LETSRIQKES |
|
ISSLSPKLRE |
| TGSSVETSSA |
|
IETSAVLSEV |
|
SIGATTEISR |
|
TEVTSSSRTS |
|
ISGSAESTML |
| PEISTTRKII |
|
KFPTSPILAE |
|
SSEMTIKTQT |
|
SPPGSTSEST |
|
FTLDTSTTPS |
| LVITHSTMTQ |
|
RLPHSEITTL |
|
VSRGAGDVPR |
|
PSSLPVEETS |
|
PPSSQLSLSA |
| MISPSPVSST |
|
LPASSHSSSA |
|
SVTSLLTPGQ |
|
VKTTEVLDAS |
|
AEPETSSPPS |
| LSSTSVEILA |
|
TSEVTTDTEK |
|
IHPFSNTAVT |
|
KVGTSSSGHE |
|
SPSSVLPDSE |
| TTKATSAMGT |
|
ISIMGDTSVS |
|
TLTPALSNTR |
|
KIQSEPASSL |
|
TTRLRETSTS |
| EETSLATEAN |
|
TVLSKVSTGA |
|
TTEVSRTEAI |
|
SFSRTSMSGP |
|
EQSTMSQDIS |
| IGTIPRISAS |
|
SVLTESAKMT |
|
ITTQTGPSES |
|
TLESTLNLNT |
|
ATTPSWVETH |
| SIVIQGFPHP |
|
EMTTSMGRGP |
|
GGVSWPSPPF |
|
VKETSPPSSP |
|
LSLPAVTSPH |
| PVSTTFLAHI |
|
PPSPLPVTSL |
|
LTSGPATTTD |
|
ILGTSTEPGT |
|
SSSSSLSTTS |
| HERLTTYKDT |
|
AHTEAVHPST |
|
NTGGTNVATT |
|
SSGYKSQSSV |
|
LADSSPMCTT |
| STMGDTSVLT |
|
STPAFLETRR |
|
IQTELASSLT |
|
PGLRESSGSE |
|
GTSSGTKMST |
| VLSKVPTGAT |
|
TEISKEDVTS |
|
IPGPAQSTIS |
|
PDISTRTVSW |
|
FSTSPVMTES |
| AEITMNTHTS |
|
PLGATTQGTS |
|
TLDTSSTTSL |
|
TMTHSTISQG |
|
FSHSQMSTLM |
| RRGPEDVSWM |
|
SPPLLEKTRP |
|
SFSLMSSPAT |
|
TSPSPVSSTL |
|
PESISSSPLP |
| VTSLLTSGLA |
|
KTTDMLHKSS |
|
EPVTNSPANL |
|
SSTSVEILAT |
|
SEVTTDTEKT |
| HPSSNRTVTD |
|
VGTSSSGHES |
|
TSFVLADSQT |
|
SKVTSPMVIT |
|
STMEDTSVST |
| STPGFFETSR |
|
IQTEPTSSLT |
|
LGLRKTSSSE |
|
GTSLATEMST |
|
VLSGVPTGAT |
| AEVSRTEVTS |
|
SSRTSISGFA |
|
QLTVSPETST |
|
ETITRLPTSS |
|
IMTESAEMMI |
| KTQTDPPGST |
|
PESTHTVDIS |
|
TTPNWVETHS |
|
TVTQRFSHSE |
|
MTTLVSRSPG |
| DMLWPSQSSV |
|
EETSSASSLL |
|
SLPATTSPSP |
|
VSSTLVEDFP |
|
SASLPVTSLL |
| NPGLVITTDR |
|
MGISREPGTS |
|
STSNLSSTSH |
|
ERLTTLEDTV |
|
DTEDMQPSTH |
| TAVTNVRTSI |
|
SGHESQSSVL |
|
SDSETPKATS |
|
PMGTTYTMGE |
|
TSVSISTSDF |
| FETSRIQIEP |
|
TSSLTSGLRE |
|
TSSSERISSA |
|
TEGSTVLSEV |
|
PSGATTEVSR |
| TEVISSRGTS |
|
MSGPDQFTIS |
|
PDISTEAITR |
|
LSTSPIMTES |
|
AESAITIETG |
| SPGATSEGTL |
|
TLDTSTTTFW |
|
SGTHSTASPG |
|
FSHSEMTTLM |
|
SRTPGDVPWP |
| SLPSVEEASS |
|
VSSSLSSPAM |
|
TSTSFFSTLP |
|
ESISSSPHPV |
|
TALLTLGPVK |
| TTDMLRTSSE |
|
PETSSPPNLS |
|
STSAEILATS |
|
EVTKDREKIH |
|
PSSNTPVVNV |
| GTVIYKHLSP |
|
SSVLADLVTT |
|
KPTSPMATTS |
|
TLGNTSVSTS |
|
TPAFPETMMT |
| QPTSSLTSGL |
|
REISTSQETS |
|
SATERSASLS |
|
GMPTGATTKV |
|
SRTEALSLGR |
| TSTPGPAQST |
|
ISPEISTETI |
|
TRISTPLTTT |
|
GSAEMTITPK |
|
TGHSGASSQG |
| TFTLDTSSRA |
|
SWPGTHSAAT |
|
HRSPHSGMTT |
|
PMSRGPEDVS |
|
WPSRPSVEKT |
| SPPSSLVSLS |
|
AVTSPSPLYS |
|
TPSESSHSSP |
|
LRVTSLFTPV |
|
MMKTTDMLDT |
| SLEPVTTSPP |
|
SMNITSDESL |
|
ATSKATMETE |
|
AIQLSENTAV |
|
TQMGTISARQ |
| EFYSSYPGLP |
|
EPSKVTSPVV |
|
TSSTIKDIVS |
|
TTIPASSEIT |
|
RIEMESTSTL |
| TPTPRETSTS |
|
QEIHSATKPS |
|
TVPYKALTSA |
|
TIEDSMTQVM |
|
SSSRGPSPDQ |
| STMSQDISTE |
|
VITRLSTSPI |
|
KTESTEMTIT |
|
TQTGSPGATS |
|
RGTLTLDTST |
| TFMSGTHSTA |
|
SQGFSHSQMT |
|
ALMSRTPGDV |
|
PWLSHPSVEE |
|
ASSASFSLSS |
| PVMTSSSPVS |
|
STLPDSIHSS |
|
SLPVTSLLTS |
|
GLVKTTELLG |
|
TSSEPETSSP |
| PNLSSTSAEI |
|
LAITEVTTDT |
|
EKLEMTNVVT |
|
SGYTHESPSS |
|
VLADSVTTKA |
| TSSMGITYPT |
|
GDTNVLTSTP |
|
AFSDTSRIQT |
|
KSKLSLTPGL |
|
METSISEETS |
| SATEKSTVLS |
|
SVPTGATTEV |
|
SRTEAISSSR |
|
TSIPGPAQST |
|
MSSDTSMETI |
| TRISTPLTRK |
|
ESTDMAITPK |
|
TGPSGATSQG |
|
TFTLDSSSTA |
|
SWPGTHSATT |
| QRFPQSVVTT |
|
PMSRGPEDVS |
|
WPSPLSVEKN |
|
SPPSSLVSSS |
|
SVTSPSPLYS |
| TPSGSSHSSP |
|
VPVTSLFTSI |
|
MMKATDMLDA |
|
SLEPETTSAP |
|
NMNITSDESL |
| AASKATTETE |
|
AIHVFENTAA |
|
SHVETTSATE |
|
ELYSSSPGFS |
|
EPTKVISPVV |
| TSSSIRDNMV |
|
STTMPGSSGI |
|
TRIEIESMSS |
|
LTPGLRETRT |
|
SQDITSSTET |
| STVLYKMPSG |
|
ATPEVSRTEV |
|
MPSSRTSIPG |
|
PAQSTMSLDI |
|
SDEVVTRLST |
| SPIMTESAEI |
|
TITTQTGYSL |
|
ATSQVTLPLG |
|
TSMTFLSGTH |
|
STMSQGLSHS |
| EMTNLMSRGP |
|
ESLSWTSPRF |
|
VETTRSSSSL |
|
TSLPLTTSLS |
|
PVSSTLLDSS |
| PSSPLPVTSL |
|
ILPGLVKTTE |
|
VLDTSSEPKT |
|
SSSPNLSSTS |
|
VEIPATSEIM |
| TDTEKIHPSS |
|
NTAVAKVRTS |
|
SSVHESHSSV |
|
LADSETTITI |
|
PSMGITSAVD |
| DTTVFTSNPA |
|
FSETRRIPTE |
|
PTFSLTPGFR |
|
ETSTSEETTS |
|
ITETSAVLYG |
| VPTSATTEVS |
|
MTEIMSSNRI |
|
HIPDSDQSTM |
|
SPDIITEVIT |
|
RLSSSSMMSE |
| STQMTITTQK |
|
SSPGATAQST |
|
LTLATTTAPL |
|
ARTHSTVPPR |
|
FLHSEMTTLM |
| SRSPENPSWK |
|
SSLFVEKTSS |
|
SSSLLSLPVT |
|
TSPSVSSTLP |
|
QSIPSSSFSV |
| TSLLTPGMVK |
|
TTDTSTEPGT |
|
SLSPNLSGTS |
|
VEILAASEVT |
|
TDTEKIHPSS |
| SMAVTNVGTT |
|
SSGHELYSSV |
|
SIHSEPSKAT |
|
YPVGTPSSMA |
|
ETSISTSMPA |
| NFETTGFEAE |
|
PFSHLTSGFR |
|
KTNMSLDTSS |
|
VTPTNTPSSP |
|
GSTHLLQSSK |
| TDFTSSAKTS |
|
SPDWPPASQY |
|
TEIPVDIITP |
|
FNASPSITES |
|
TGITSFPESR |
| FTMSVTESTH |
|
HLSTDLLPSA |
|
ETISTGTVMP |
|
SLSEAMTSFA |
|
TTGVPRAISG |
| SGSPFSRTES |
|
GPGDATLSTI |
|
AESLPSSTPV |
|
PFSSSTFTTT |
|
DSSTIPALHE |
| ITSSSATPYR |
|
VDTSLGTESS |
|
TTEGRLVMVS |
|
TLDTSSQPGR |
|
TSSSPILDTR |
| MTESVELGTV |
|
TSAYQVPSLS |
|
TRLTRTDGIM |
|
EHITKIPNEA |
|
AHRGTIRPVK |
| GPQTSTSPAS |
|
PKGLHTGGTK |
|
RMETTTTALK |
|
TTTTALKTTS |
|
RATLTTSVYT |
| PTLGTLTPLN |
|
ASMQMASTIP |
|
TEMMITTPYV |
|
FPDVPETTSS |
|
LATSLGAETS |
| TALPRTTPSV |
|
FNRESETTAS |
|
LVSRSGAERS |
|
PVIQTLDVSS |
|
SEPDTTASWV |
| IHPAETIPTV |
|
SKTTPNFFHS |
|
ELDTVSSTAT |
|
SHGADVSSAI |
|
PTNISPSELD |
| ALTPLVTISG |
|
TDTSTTFPTL |
|
TKSPHETETR |
|
TTWLTHPAET |
|
SSTIPRTIPN |
| FSHHESDATP |
|
SIATSPGAET |
|
SSAIPIMTVS |
|
PGAEDLVTSQ |
|
VTSSGTDRNM |
| TIPTLTLSPG |
|
EPKTIASLVT |
|
HPEAQTSSAI |
|
PTSTISPAVS |
|
RLVTSMVTSL |
| AAKTSTTNRA |
|
LTNSPGEPAT |
|
TVSLVTHPAQ |
|
TSPTVPWTTS |
|
IFFHSKSDTT |
| PSMTTSHGAE |
|
SSSAVPTPTV |
|
STEVPGVVTP |
|
LVTSSRAVIS |
|
TTIPILTLSP |
| GEPETTPSMA |
|
TSHGEEASSA |
|
IPTPTVSPGV |
|
PGVVTSLVTS |
|
SRAVTSTTIP |
| ILTFSLGEPE |
|
TTPSMATSHG |
|
TEAGSAVPTV |
|
LPEVPGMVTS |
|
LVASSRAVTS |
| TTLPTLTLSP |
|
GEPETTPSMA |
|
TSHGAEASST |
|
VPTVSPEVPG |
|
VVTSLVTSSS |
| GVNSTSIPTL |
|
ILSPGELETT |
|
PSMATSHGAE |
|
ASSAVPTPTV |
|
SPGVSGVVTP |
| LVTSSRAVTS |
|
TTIPILTLSS |
|
SEPETTPSMA |
|
TSHGVEASSA |
|
VLTVSPEVPG |
| MVTSLVTSSR |
|
AVTSTTIPTL |
|
TISSDEPETT |
|
TSLVTHSEAK |
|
MISAIPTLAV |
| SPTVQGLVTS |
|
LVTSSGSETS |
|
AFSNLTVASS |
|
QPETIDSWVA |
|
HPGTEASSVV |
| PTLTVSTGEP |
|
FTNISLVTHP |
|
AESSSTLPRT |
|
TSRFSHSELD |
|
TMPSTVTSPE |
| AESSSAISTT |
|
ISPGIPGVLT |
|
SLVTSSGRDI |
|
SATFPTVPES |
|
PHESEATASW |
| VTHPAVTSTT |
|
VPRTTPNYSH |
|
SEPDTTPSIA |
|
TSPGAEATSD |
|
FPTITVSPDV |
| PDMVTSQVTS |
|
SGTDTSITIP |
|
TLTLSSGEPE |
|
TTTSFITYSE |
|
THTSSAIPTL |
| PVSPGASKML |
|
TSLVISSGTD |
|
STTTFPTLTE |
|
TPYEPETTAI |
|
QLIHPAETNT |
| MVPRTTPKFS |
|
HSKSDTTLPV |
|
AITSPGPEAS |
|
SAVSTTTISP |
|
DMSDLVTSLV |
| PSSGTDTSTT |
|
FPTLSETPYE |
|
PETTATWLTH |
|
PAETSTTVSG |
|
TIPNFSHRGS |
| DTAPSMVTSP |
|
GVDTRSGVPT |
|
TTIPPSIPGV |
|
VTSQVTSSAT |
|
DTSTAIPTLT |
| PSPGEPETTA |
|
SSATHPGTQT |
|
GFTVPIRTVP |
|
SSEPDTMASW |
|
VTHPPQTSTP |
| VSRTTSSFSH |
|
SSPDATPVMA |
|
TSPRTEASSA |
|
VLTTISPGAP |
|
EMVTSQITSS |
| GAATSTTVPT |
|
LTHSPGMPET |
|
TALLSTHPRT |
|
ETSKTFPAST |
|
VFPQVSETTA |
| SLTIRPGAET |
|
STALPTQTTS |
|
SLFTLLVTGT |
|
SRVDLSPTAS |
|
PGVSAKTAPL |
| STHPGTETST |
|
MIPTSTLSLG |
|
LLETTGLLAT |
|
SSSAETSTST |
|
LTLTVSPAVS |
| GLSSASITTD |
|
KPQTVTSWNT |
|
ETSPSVTSVG |
|
PPEFSRTVTG |
|
TTMTLIPSEM |
| PTPPKTSHGE |
|
GVSPTTILRT |
|
TMVEATNLAT |
|
TGSSPTVAKT |
|
TTTFNTLAGS |
| LFTPLTTPGM |
|
STLASESVTS |
|
RTSYNHRSWI |
|
STTSSYNRRY |
|
WTPATSTPVT |
| STFSPGISTS |
|
SIPSSTAATV |
|
PFMVPFTLNF |
|
TITNLQYEED |
|
MRHPGSRKFN |
| ATERELQGLL |
|
KPLFRNSSLE |
|
YLYSGCRLAS |
|
LRPEKDSSAT |
|
AVDAICTHRP |
| DPEDLGLDRE |
|
RLYWELSNLT |
|
NGIQELGPYT |
|
LDRNSLYVNG |
|
FTHRSSMPTT |
| STPGTSTVDV |
|
GTSGTPSSSP |
|
SPTTAGPLLM |
|
PFTLNFTITN |
|
LQYEEDMRRT |
| GSRKFNTMES |
|
VLQGLLKPLF |
|
KNTSVGPLYS |
|
GCRLTLLRPE |
|
KDGAATGVDA |
| ICTHRLDPKS |
|
PGLNREQLYW |
|
ELSKLTNDIE |
|
ELGPYTLDRN |
|
SLYVNGFTHQ |
| SSVSTTSTPG |
|
TSTVDLRTSG |
|
TPSSLSSPTI |
|
MAAGPLLVPF |
|
TLNFTITNLQ |
| YGEDMGHPGS |
|
RKFNTTERVL |
|
QGLLGPIFKN |
|
TSVGPLYSGC |
|
RLTSLRSEKD |
| GAATGVDAIC |
|
IHHLDPKSPG |
|
LNRERLYWEL |
|
SQLTNGIKEL |
|
GPYTLDRNSL |
| YVNGFTHRTS |
|
VPTSSTPGTS |
|
TVDLGTSGTP |
|
FSLPSPATAG |
|
PLLVLFTLNF |
| TITNLKYEED |
|
MHRPGSRKFN |
|
TTERVLQTLL |
|
GPMFKNTSVG |
|
LLYSGCRLTL |
| LRSEKDGAAT |
|
GVDAICTHRL |
|
DPKSPGVDRE |
|
QLYWELSQLT |
|
NGIKELGPYT |
| LDRNSLYVNG |
|
FTHWIPVPTS |
|
STPGTSTVDL |
|
GSGTPSSLPS |
|
PTTAGPLLVP |
| FTLNFTITNL |
|
KYEEDMHCPG |
|
SRKFNTTERV |
|
LQSLLGPMFK |
|
NTSVGPLYSG |
| CRLTLLRSEK |
|
DGAATGVDAI |
|
CTHRLDPKSP |
|
GVDREQLYWE |
|
LSQLTNGIKE |
| LGPYTLDRNS |
|
LYVNGFTHQT |
|
SAPNTSTPGT |
|
STVDLGTSGT |
|
PSSLPSPTSA |
| GPLLVPFTLN |
|
FTITNLQYEE |
|
DMHHPGSRKF |
|
NTTERVLQGL |
|
LGPMFKNTSV |
| GLLYSGCRLT |
|
LLRPEKNGAA |
|
TGMDAICSHR |
|
LDPKSPGLNR |
|
EQLYWELSQL |
| THGIKELGPY |
|
TLDRNSLYVN |
|
GFTHRSSVAP |
|
TSTPGTSTVD |
|
LGTSGTPSSL |
| PSPTTAVPLL |
|
VPFTLNFTIT |
|
NLQYGEDMRH |
|
PGSRKFNTTE |
|
RVLQGLLGPL |
| FKNSSVGPLY |
|
SGCRLISLRS |
|
EKDGAATGVD |
|
AICTHHLNPQ |
|
SPGLDREQLY |
| WQLSQMTNGI |
|
KELGPYTLDR |
|
NSLYVNGFTH |
|
RSSGLTTSTP |
|
WTSTVDLGTS |
| GTPSPVPSPT |
|
TTGPLLVPFT |
|
LNFTITNLQY |
|
EENMGHPGSR |
|
KFNITESVLQ |
| GLLKPLFKST |
|
SVGPLYSGCR |
|
LTLLRPEKDG |
|
VATRVDAICT |
|
HRPDPKIPGL |
| DRQQLYWELS |
|
QLTHSITELG |
|
PYTLDRDSLY |
|
VNGFTQRSSV |
|
PTTSTPGTFT |
| VQPETSETPS |
|
SLPGPTATGP |
|
VLLPFTLNFT |
|
ITNLQYEEDM |
|
RRPGSRKFNT |
| TERVLQGLLM |
|
PLFKNTSVSS |
|
LYSGCRLTLL |
|
RPEKDGAATR |
|
VDAVCTHRPD |
| PKSPGLDRER |
|
LYWKLSQLTH |
|
GITELGPYTL |
|
DRHSLYVNGF |
|
THQSSMTTTR |
| TPDTSTMHLA |
|
TSRTPASLSG |
|
PMTASPLLVL |
|
FTINFTITNL |
|
RYEENMHHPG |
| SRKFNTTERV |
|
LQGLLRPVFK |
|
NTSVGPLYSG |
|
CRLTLLRPKK |
|
DGAATKVDAI |
| CTYRPDPKSP |
|
GLDREQLYWE |
|
LSQLTHSITE |
|
LGPYTLDRDS |
|
LYVNGFTQRS |
| SVPTTSIPGT |
|
PTVDLGTSGT |
|
PVSKPGPSAA |
|
SPLLVLFTLN |
|
FTITNLRYEE |
| NMQHPGSRKF |
|
NTTERVLQGL |
|
LRSLFKSTSV |
|
GPLYSGCRLT |
|
LLRPEKDGTA |
| TGVDAICTHH |
|
PDPKSPRLDR |
|
EQLYWELSQL |
|
THNITELGPY |
|
ALDNDSLFVN |
| GFTHRSSVST |
|
TSTPGTPTVY |
|
LGASKTPASI |
|
FGPSAASHLL |
|
ILFTLNFTIT |
| NLRYEENMWP |
|
GSRKFNTTER |
|
VLQGLLRPLF |
|
KNTSVGPLYS |
|
GCRLTLLRPE |
| KDGEATGVDA |
|
ICTHRPDPTG |
|
PGLDREQLYL |
|
ELSQLTHSIT |
|
ELGPYTLDRD |
| SLYVNGFTHR |
|
SSVPTTSTGV |
|
VSEEPFTLNF |
|
TINNLRYMAD |
|
MGQPGSLKFN |
| ITDNVMQHLL |
|
SPLFQRSSLG |
|
ARYTGCRVIA |
|
LRSVKNGAET |
|
RVDLLCTYLQ |
| PLSGPGLPIK |
|
QVFHELSQQT |
|
HGITRLGPYS |
|
LDKDSLYLNG |
|
YNEPGPDEPP |
| TTPKPATTFL |
|
PPLSEATTAM |
|
GYHLKTLTLN |
|
FTISNLQYSP |
|
DMGKGSATFN |
| STEGVLQHLL |
|
RPLFQKSSMG |
|
PFYLGCQLIS |
|
LRPEKDGAAT |
|
GVDTTCTYHP |
| DPVGPGLDIQ |
|
QLYWELSQLT |
|
HGVTQLGFYV |
|
LDRDSLFING |
|
YAPQNLSIRG |
| EYQINFHIVN |
|
WNLSNPDPTS |
|
SEYITLLRDI |
|
QDKVTTLYKG |
|
SQLHDTFRFC |
| LVTNLTMDSV |
|
LVTVKALFSS |
|
NLDPSLVEQV |
|
FLDKTLNASF |
|
HWLGSTYQLV |
| DIHVTEMESS |
|
VYQPTSSSST |
|
QHFYLNFTIT |
|
NLPYSQDKAQ |
|
PGTTNYQRNK |
| RNIEDALNQL |
|
FRNSSIKSYF |
|
SDCQVSTFRS |
|
VPNRHHTGVD |
|
SLCNFSPLAR |
| RVDRVAIYEE |
|
FLRMTRNGTQ |
|
LQNFTLDRSS |
|
VLVDGYSPNR |
|
NEPLTGNSDL |
| PFWAVILIGL |
|
AGLLGVITCL |
|
ICGVLVTTRR |
|
RKKEGEYNVQ |
|
QQCPGYYQSH |
| LDLEDLQ |
Кодований геном білок за функцією належить до фосфопротеїнів.
Локалізований у клітинній мембрані, а його фрагмент також секретований назовні.
Фізіологічна роль
Муцин-16 синтезується в клітинах епітелію бронхів, ендометрію, яєчників, рогівки. Низка протеаз, зокрема еластаза нейтрофілів, MMP7, MMP9, бактеріальна металопротеаза ZmpC тощо, здатні відщеплювати позаклітинну частину білка від трансмембранного якоря. Функція білка в здорових клітинах маловивчена, хоча встановлено, що в епітелії ока муцин-16 взаємодіє з галектином-3 та цей комплекс захищає око від вірусних та бактеріальних інфекцій.
Медичне значення
1981 року група американських онкологів під керівництвом Роберта Баста (англ. Robert C. Bast) розробила моноклональне антитіло OC125, яке позитивно реагувало з тканиною злоякісної пухлини яєчника, але не взаємодіяло з іншими типами пухлин цього органу. Невідомий на той час білок, який розпізнавало це антитіло, був названий CA125 (від англ. Cancer Antigen). Попри те, що антитіло було створено задля лікування цього виду раку, надалі його почали використовувати для діагностики, зокрема щодо рецидивів раку яєчників. 2001 року було клоновано ген, який кодує цей білок, який виявився приналежним до родини муцинів.
Висока експресія білка на поверхні ракових клітин захищає їх від моноцитів та природних кілерів.
Див. також
Література
-
O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K. (2002). The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure.. Tumor Biol. 23: 154 — 169. PubMed DOI:10.1159/000064032
-
Yin B.W.T., Lloyd K.O. (2001). Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16.. J. Biol. Chem. 276: 27371 — 27375. PubMed DOI:10.1074/jbc.M103554200
-
McLemore M.R., Aouizerat B. (2005). Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer.. Biol. Res. Nurs. 6: 262 — 267. PubMed DOI:10.1177/1099800404274445
-
Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K. (2006). Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye.. Invest. Ophthalmol. Vis. Sci. 47: 113 — 119. PubMed DOI:10.1167/iovs.05-0735
